Kassadin's ultimate has many uses and is on a shorter cooldown than most, use it often.
Kassadin has multiple item paths; he can go caster via Mana and Ability Power or anti-caster with Cooldown Reduction and Magic Resist.
Try to get the Ancient Golem buff to counteract Riftwalk's increasing Mana cost.
Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stat comparisons provided here show several important Kassadin against Vayne counter statistics that can help you understand the differences between the two. Kassadin’s KDA ratio ([kills + assists] / deaths) of NaN is better than Vayne’s ratio of NaN, demonstrating that Kassadin may be more central to his team's team fighting potential than Vayne..
Kassadin normally has a similar longest killing spree as his opponent does. On average, he receives more damage than Vayne. This typically indicates differing health capacities; however, it can also hint that the one champ has less agility and thus is not able to escape further damage when engaged or poked.
Both League of Legends champs are great. Both champs have their strengths, weaknesses, and counters. In League's current meta, Kassadin usually fairs equally well when trying to fight Vayne, with a 49.2% win rate. As a result, Kassadin makes an ok counter to Vayne.
While Kassadin does have a lower win rate compared to Vayne, when facing one another, Kassadin also has a greater difficulty level that makes him a more difficult champion to learn and master. You should be careful when picking Kassadin into Vayneas his relative depth means that you may not be able to reach his full potential without a significant amount of practice beforehand.
Moreover, Kassadin has some amount of utility and CC, a similar amount to Vayne. This makes her just as valuable during teamfights, especially when trying to counter champions with a lot of burst damage.
While there isn't a single best champion in League of Legends, in Kassadin vs Vayne matchups, Vayne is the better champion with a similar win rate, similar champion depth, and a similar amount of utility to help out your allies during late stage team fights.
Kassadin is a somewhat poor counter for Vayne. Focus your strategy on maximizing your gold and cs and clearing objectives. If you can do that, you should do very well as Kassadin against Vayne.
To truly master Kassadin to counter Vayne during both the laning and mid / late game phases of League of Legends, you should continue reading to gather a few extra lessons on this matchup. If you mind the build and stats shown above, you will increase your win rate by a lot and be that much closer to League of Legends pro players.
Kassadin most often accumulates a similar amount of CS as Vayne. Champions who typically don't earn much CS often don't need much CS to be valuable teammates, such as support champions. These kinds of champions are able to scale well off of their abilities and first items alone. Yet, champs with a lot of CS, such as hyper-carries, often require several high cost items to be effective. In either situation, try to surpass the numbers reported on this page to do well.
The best items to focus on in your Kassadin versus Vayne build consist of Seraph's Embrace, Rabadon's Deathcap, and Malignance. When Kassadin incorporated at least these three pieces in his build, he performed a lot better versus Vayne than with most other commonly used builds. In fact, Kassadin boasted an average winrate of 49.2% battling Vayne with these items in his kit.
To have the highest probability of crushing Vayne as Kassadin, Kassadin players should use the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Sudden Impact, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Of all the rune builds players chose for Kassadin vs Vayne matchups, this set of runes resulted in the greatest win rate. Notably, these runes provided a 49.2% winrate overall.
If you need to see Kassadin vs Vayne tips and counter builds for a an individual division, please select one from the selection menu provided above. If viewing for the first time, the statistics and guides shown are calculated using every match completed with these champs.