Kassadin's ultimate has many uses and is on a shorter cooldown than most, use it often.
Kassadin has multiple item paths; he can go caster via Mana and Ability Power or anti-caster with Cooldown Reduction and Magic Resist.
Try to get the Ancient Golem buff to counteract Riftwalk's increasing Mana cost.
Kai'Sa is very vulnerable to getting outranged by mages and long range carries.
Make sure to place wards in your blind spots so you can see Kai'Sa coming.
Kai'Sa is very good at picking off isolated enemies. Stick together against her.
The stat comparisons provided here clarify several strategic Kassadin vs. Kai'Sa matchup stats that may help you realize the differences between these two champs. For instance, Kassadin’s KDA ratio ([kills + assists] / deaths) of NaN is more than Kai'Sa’s ratio of NaN, demonstrating that Kassadin may be more central to his team's team fighting capacity than Kai'Sa..
Kassadin usually has a similar longest kill spree as his foe does. On average, he receives more damage than Kai'Sa. This commonly reflects differing health capacities, yet it can also show that the champion with increased health has less mobility and thus is not able to escape additional damage when engaged or poked.
Both LoL champs are great champions. Both champs have their pros and cons. In the game's current meta, Kassadin usually wins when facing off against Kai'Sa, with a 53.8% win rate. As a result, Kassadin makes a great counter to Kai'Sa.
While Kassadin does have a higher winrate compared to Kai'Sa, when facing one another, Kassadin also has a greater difficulty level that makes him a more complex character to pick up and master. You don't need to be too worried when picking Kassadin into Kai'Saas his relative depth means that you may not be able to unleash his full potential without a lot of practice beforehand.
Additionally, Kassadin also has some amount of CC and other utility, a similar amount to Kai'Sa. This often makes her just as valuable during teamfights, especially when facing champions with a lot of burst damage.
While there isn't a single best champion for every situation in League of Legends, in Kassadin vs Kai'Sa matchups, Kassadin is the better champ with a noticably higher win rate, more champion depth, and a similar amount of utility to help out your allied champions during teamfights.
Kassadin is a great counter for Kai'Sa. Focus your strategy on maximizing your CS and clearing objectives. If you can do that, you should be able to stand on your own as Kassadin against Kai'Sa.
If you would like to learn all of the intricacies of Kassadin to counter Kai'Sa during both the laning and mid / late game phases of League of Legends, you should keep reading to pick up a few extra lessons on this matchup. If you pay attention to the build and suggestions shown above, you should grow your win rate by a lot and be that much closer to League of Legends pro players.
Kassadin often racks up a similar amount of CS compared to Kai'Sa. Champions who on average don't earn many minion kills often don't require much CS to be effective, such as support champions. These kinds of champions are able to scale properly off of their abilities and first items alone. Yet, champions with a lot of CS, such as hyper-carries, usually need a lot of items to be effective. In either case, try to surpass the numbers reported here to do well.
The top items to use in your Kassadin versus Kai'Sa build consist of Seraph's Embrace, Luden's Companion, and Rod of Ages. When Kassadin combined at least these three items in his build, he did much better countering Kai'Sa than with many other commonly used item sets. In fact, Kassadin boasted an average win rate of 53.8% when playing against Kai'Sa with these items in his kit.
To have the highest chance of vanquishing Kai'Sa as Kassadin, you should use the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Sudden Impact, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Out of all the rune builds we have analyed for Kassadin vs Kai'Sa counterpicks, this sequence of runes yielded the highest win rate. Notably, these runes provided a 53.8% winrate overall.
If you want to view Kassadin versus Kai'Sa tips and counter stats for a a specific division, feel free to choose one from the selection menu shown above. If viewing for the first time, the statistics and build suggestions given are computed using all matches played with both champions.