Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The stat comparisons provided here highlight some vital Karthus versus Zeri counter stats that may help you interpret the differences and similarities between the pair. For instance, Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is more than Zeri’s KDA ratio of NaN, demonstrating that Karthus may be more central to his team's team fighting potential than Zeri..
Karthus usually has a similar longest kill spree as his enemy does. Commonly, he takes a similar amount of damage to Zeri. This commonly reflects differing health capacities; however, it can also show that the one champion has less mobility and thus is not able to kite away from additional damage when poked or engaged.
Both League of Legends champs are great. Both have their strengths, weaknesses, and counters. In League's current meta, Karthus usually wins when playing against Zeri, with a 52.8% win rate. Therefore, Karthus makes a good counter for Zeri.
While Karthus does have a higher win rate than Zeri, when on opposite teams, Karthus also has a greater learning curve that makes him a more time consuming champion to learn. You should be be fine when picking Karthus into Zerias his relative depth means you may not be able to reach his full potential without a significant amount of practice beforehand.
Additionally, Karthus also has some amount of utility and CC, a similar amount to Zeri. This often makes her just as valuable during teamfights, especially when fighting champions with a ton of burst damage.
While there is not one best champion in League of Legends, in Karthus vs Zeri matchups, Karthus is the better champion with a noticably higher win rate, more champion depth, and a similar amount of utility to help out your allied champions during team fights.
Karthus is an above average counter for Zeri. Focus your strategy on maximizing your gold and cs and taking out objectives. If you do that, you should do very well as Karthus against Zeri.
If you would like to truly master Karthus to counter Zeri during both the laning and mid / late game phases of League of Legends, you should continue reading to pick up a few extra tips and tricks for this matchup. If you mind the build and suggestions displayed above, you will grow your win rate significantly and be closer to League of Legends pro players.
Karthus on average racks up less CS compared to Zeri. Champs who on average don't get many minion kills typically don't have to have much CS to be valuable teammates, such as supports. These kinds of champions are able to scale well off of their skills, stats, and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, usually need many items to be effective. In either situation, try to do better than the numbers shown here to do well.
The most crucial items to prioritize in your Karthus versus Zeri build include Rabadon's Deathcap, Malignance, and Shadowflame. When Karthus combined at least these three pieces in his build, he performed much better vs Zeri than with many other commonly used item sets. In fact, Karthus boasted an average win rate of 52.8% battling Zeri with this counter build.
To have the greatest likelihood of coming out on top against Zeri as Karthus, Karthus players should take the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Of all the runes players used for Karthus vs Zeri fights, this mix of runes yielded the best win rate. Notably, these runes gave a 52.8% win rate overall.
If you need to get Karthus vs Zeri tips and builds for a a specific rank, feel free to select one from the selection menu provided above. At first, the stats and strategies given are computed using all rounds with data with both champions.