Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Items that counter Health stacking, such as Liandry's Torment and Blade of the Ruined King, are very effective against Vladimir.
Making Vladimir use Sanguine Pool at the start of a fight will maximize the Health cost of the ability to him.
Try to take Vladimir down before Hemoplague detonates, as it will heal him for each afflicted enemy Champion.
The stat comparisons shown on this page clarify several strategic Karthus versus Vladimir counter stats that can help you grasp the differences and similarities between this set of champs. Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is more than Vladimir’s ratio of NaN, showing that Karthus may be more central to his team's team fighting capability than Vladimir. This observation is in large part fueled by the differences in deaths.
Karthus usually has a similar longest killing spree as his foe does. Commonly, he receives less damage than Vladimir. This often reflects different amounts of tankyness; however, it can also hint that the champion with increased HP has less agility and thus is unable to kite away from further damage when poked or engaged.
Both LoL champions are great champions. Both have their pros and cons. In the game's current meta, Karthus usually loses when playing against Vladimir, with a 45.3% win rate. Therefore, Karthus makes a poor counter for Vladimir.
While Karthus does have a much lower win rate compared to Vladimir, when on opposite teams, Karthus also has a greater difficulty level that makes him a more difficult character to develop with. You may get destroyed when picking Karthus into Vladimiras his relative depth means you may not be able to reach his full potential without a lot of practice beforehand.
Additionally, Karthus has some amount of utility and CC, a similar amount to Vladimir. This often makes her just as valuable during team fights, especially when trying to counter champions with a lot of burst damage.
While there isn't one best champion in League of Legends, in Karthus vs Vladimir matchups, Vladimir is the better champ with a much lower win rate, similar champion depth, and a similar amount of utility to help out your allied champions during team fights.
Karthus is a terribly counter to Vladimir. You will do well by focussing your gameplay on increasing your gold income and destroying objectives. If you are able to do that, you should hold your own as Karthus against Vladimir.
To learn all of the intricacies of Karthus to counter Vladimir during both the early game and mid / late game phases of League of Legends, you should keep reading to learn a few extra tips and tricks for this matchup. If you mind the build and stats displayed here, you will grow your win rate by a lot and be that much closer to League of Legends pro players.
Karthus on average picks up less CS as Vladimir. Champs who on average don't get much CS typically don't require much CS to be valuable teammates, such as sup champs. They are able to scale well off of their abilities and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, often need many items to be effective. In either case, try to surpass the values displayed on this page to do well.
The top items to use in your Karthus versus Vladimir build consist of Rabadon's Deathcap, Malignance, and Stormsurge. When Karthus combined at least these three pieces in his build, he did much better versus Vladimir than with many other typical item sets. In fact, Karthus had an average win rate of 45.3% when countering Vladimir with these items in his kit.
To have the greatest chance of annihilating Vladimir as Karthus, you should equip the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Presence of Mind, and Last Stand runes from the Domination and Precision rune sets. Of all the rune builds we have analyed for Karthus vs Vladimir counters, this composite of runes resulted in the greatest win rate. Notably, these runes averaged a 45.3% winrate overall.
If you would like to see Karthus vs Vladimir tips and counter builds for a a specific skill level, please choose one from the selection menu displayed above. At first, the stats and build suggestions shown are computed using every match completed with both champs.