Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The stats shown on this page show several important Karthus vs. Vex counter stats that may help you understand the differences between this pair of champs. For instance, Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is better than Vex’s ratio of NaN, indicating that Karthus may be more central to his team's team fighting capability than Vex..
Karthus normally has a similar longest killing spree as his counter does. Commonly, he takes more damage than Vex. This often reflects different amounts of tankyness, but it can also illustrate that the champion with increased health has less agility and thus is unable to kite away from additional harm when poked or engaged.
Both LoL champions are great champions. Both have their pros and cons. In League's current meta, Karthus usually loses when playing against Vex, with a 48.0% win rate. Thus, Karthus makes a bad counter to Vex.
While Karthus does have a lower winrate than Vex, when they face off with one another, Karthus also has a much greater level of difficulty that makes him a more complex champion to develop with. You should expect to face a difficult match when picking Karthus into Vexas his relative depth means that you may not be able to unleash his full potential without a significant amount of practice beforehand.
Furthermore, Karthus has some amount of utility and CC, a similar amount to Vex. This makes her just as valuable during teamfights, especially when facing champions with a ton of burst damage.
While there isn't one best champion for every situation in League of Legends, in Karthus vs Vex matchups, Vex is the better champion with a lower win rate, more champion depth, and a similar amount of utility to help out your team members during late stage team fights.
Karthus is a trash counter for Vex. Focus your tactics on increasing your CS and clearing objectives. If you are able to do that, you should be able to stand on your own as Karthus against Vex.
If you would like to truly master Karthus in order to counter Vex during both the early game and mid / late game phases of League of Legends, you should continue reading to learn a few extra tricks and insights into this matchup. If you pay attention to the build and suggestions shown here, you will grow your win rate significantly and be that much closer to League of Legends pro players.
Karthus typically racks up less CS relative to Vex. Champs who typically don't take much CS usualy don't require much CS to be valuable teammates, such as support champions. They are capable of scaling properly off of their abilities and first items alone. Yet, champs with a lot of CS, such as hyper-carries, often have to have several high cost items to be effective. In either situation, try to do better than the numbers shown here to do well.
The most crucial items to use in your Karthus versus Vex build consist of Malignance, Stormsurge, and Liandry's Torment. When Karthus combined at least these three items in his build, he did much better against Vex than with most other common builds. In fact, Karthus boasted an average win rate of 48.0% battling Vex with this counter build.
To have the best probability of crushing Vex as Karthus, Karthus players should equip the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Gathering Storm, and Transcendence runes from the Domination and Sorcery rune sets. Of all the rune builds that we analyzed for Karthus vs Vex counter picks, this set of runes resulted in the best win rate. In fact, these runes gave a 48.0% winrate overall.
By default, tips, stats, and builds on how to beat Vex as Karthus are given for all ranked divisions combined. If you want to scope the stats and builds to a specific skill level, you may use the selection menu located earlier in the counter matchup guide.