Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Stand away from your creeps in a lane to take less collateral damage from Explosive Charge.
If you see Tristana activate Rapid Fire in a fight, stun her and try to back off until the spell dissipates.
The stat comparisons shown on this page clarify some influential Karthus vs. Tristana matchup statistics that may help us grasp the differences between the two. Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is better than Tristana’s ratio of NaN, indicating that Karthus may be more central to his team's team fighting capability than Tristana..
Karthus normally has a similar longest kill spree as his foe does. Commonly, he takes more damage than Tristana. This commonly reflects different amounts of tankyness, but it can also illustrate that the one champion has less mobility and thus is not able to escape further damage when engaged or poked.
Both LoL champs are great. Both have their pros and cons. In League's current meta, Karthus usually loses when playing against Tristana, with a 48.9% win rate. Thus, Karthus makes a bad counter to Tristana.
While Karthus does have a lower winrate than Tristana, when they face off with one another, Karthus also has a much greater learning curve that makes him a more difficult champ to pick up and master. You still need to be cautious when picking Karthus into Tristanaas his relative depth means you may not be able to unleash his full potential without a lot of practice beforehand.
Furthermore, Karthus also has some amount of utility and CC, a similar amount to Tristana. This often makes her just as valuable during teamfights, especially when facing champions with a ton of burst damage.
While there isn't one best champion overall in League of Legends, in Karthus vs Tristana matchups, Tristana is the better champ with a lower win rate, more champion depth, and a similar amount of utility to help out your allied champions during teamfights.
Karthus is a somewhat poor counter for Tristana. Focus your play on keeping up your CS and destroying objectives. If you can do that, you should hold your own as Karthus against Tristana.
If you would like to truly master Karthus to counter Tristana during both the early game and mid / late game phases of League of Legends, you should keep reading to gather a few extra lessons on this matchup. If you listen to the build and stats presented here, you will increase your win rate by a lot and be that much closer to League of Legends pro players.
Karthus on average gets less CS compared to Tristana. Champs who on average don't take many minion kills typically don't need much CS to be valuable teammates, such as supports. These kinds of champions are capable of scaling properly off of their abilities and first items alone. Yet, champions with a lot of CS, such as hyper-carries, typically have to have many items to be effective. In either situation, try to do better than the values reported on this page to do well.
The ideal items to use in your Karthus versus Tristana build consist of Rabadon's Deathcap, Malignance, and Stormsurge. When Karthus included at least these three items in his build, he did a lot better against Tristana than with most other commonly used item sets. In fact, Karthus had an average win rate of 48.9% when playing against Tristana with these items in his kit.
To have the best probability of defeating Tristana as Karthus, you should take the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Of all the rune builds we have analyed for Karthus vs Tristana counters, this sequence of runes resulted in the greatest win rate. Notably, these runes gave a 48.9% winrate overall.
If you would like to view Karthus versus Tristana tips and builds for a a particular player tier, please choose one from the selection menu above. If viewing for the first time, the statistics and strategies given are computed using all rounds played with both champs.