Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The stat comparisons shown on this page emphasize several vital Karthus vs. Senna matchup stats that can help us grasp the differences between these two champs. For instance, Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is more than Senna’s KDA ratio of NaN, indicating that Karthus may be more central to his team's team fighting potential than Senna..
Karthus usually has a slightly larger longest kill spree than his matchup does. On average, he receives more damage than Senna. This often reflects differing health capacities, yet it can also illustrate that the champion with more HP has less mobility and thus is unable to flee from additional damage when engaged or poked.
Both League champions are great. Both champs have their pros and cons. In the game's current meta, Karthus usually loses when facing off against Senna, with a 46.5% win rate. Thus, Karthus makes a bad counter to Senna.
While Karthus does have a lower win rate compared to Senna, when they face off with one another, Karthus also has a greater level of difficulty that makes him a more complex champion to pick up and master. You should be very concerned when picking Karthus into Sennaas his relative depth means that you may not be able to reach his full potential without a lot of practice beforehand.
Additionally, Karthus also has some amount of utility and CC, a similar amount to Senna. This makes her just as valuable during teamfights, especially when trying to counter champions with a lot of burst damage.
While there isn't one best champion overall in League of Legends, in Karthus vs Senna matchups, Senna is the better champion with a much lower win rate, similar champion depth, and a similar amount of utility to help out your allied champions during late stage team fights.
Karthus is a trash counter to Senna. Make sure you focus your play on increasing your gold income and destroying objectives. If you do that, you should do very well as Karthus against Senna.
To truly master Karthus to counter Senna during both the early game and mid / late game phases of League of Legends, you should continue reading to gather a few extra lessons on this matchup. If you pay attention to the build and tips shown above, you should increase your win rate by a lot and be closer to League of Legends pro players.
Karthus usually gets a similar amount of CS as Senna. Champs who typically don't earn many minion kills often don't have to have much CS to be effective, such as supports. They are able to scale well off of their abilities and first items alone. Yet, champions with large amounts of CS, such as hyper-carries, often require many items to be effective. In either case, try to do better than the values shown on this page to do well.
The most crucial items to prioritize in your Karthus versus Senna build include Rabadon's Deathcap, Malignance, and Zhonya's Hourglass. When Karthus included at least these three pieces in his build, he did significantly better when facing Senna than with most other typical counter builds. In fact, Karthus boasted an average win rate of 46.5% when playing against Senna with these items in his kit.
To have the greatest chance of annihilating Senna as Karthus, you should use the Dark Harvest, Cheap Shot, Eyeball Collection, Treasure Hunter, Coup de Grace, and Presence of Mind runes from the Domination and Precision rune sets. Out of all the rune sets players picked for Karthus vs Senna counter picks, this order of runes yielded the greatest win rate. Moreover, these runes averaged a 46.5% winrate overall.
If you need to get Karthus x Senna tips and counter builds for a a specific division rank, feel free to choose one from the selection menu provided above. If viewing for the first time, the statistics and guides given are calculated using all games finished with both champs.