Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Ryze is especially dangerous to opponents that are marked with Flux.
Use Realm Warp's windup time to figure out how to deal with what may be coming out of the portal.
Crowd controlling Ryze during Realm Warp's windup will cancel the portal.
The stats shown here highlight some valuable Karthus versus Ryze matchup statistics that may help us explain the differences between the pair. For instance, Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is more than Ryze’s ratio of NaN, showing that Karthus may be more central to his team's team fighting potential than Ryze..
Karthus usually has a similar longest killing spree as his foe does. Typically, he receives a similar amount of damage to Ryze. This is usually reflective of differing health capacities; however, it can also illustrate that the champion with increased HP has less mobility and thus is not able to escape additional damage when engaged or poked.
Both LoL champs are great champions. Both champs have their strengths, weaknesses, and counters. In the game's current meta, Karthus usually loses when trying to fight Ryze, with a 46.6% win rate. Thus, Karthus makes a bad counter for Ryze.
While Karthus does have a lower winrate than Ryze, when on opposite teams, Karthus also has a greater difficulty level that makes him a more complex character to learn and master. You should be very concerned when picking Karthus into Ryzeas his relative depth means that you may not be able to reach his full potential without a significant amount of practice beforehand.
Additionally, Karthus also has some amount of CC and other utility, a similar amount to Ryze. This often makes her just as valuable during team fights, especially when trying to counter champions with a ton of burst damage.
While there is not one best champion overall in League of Legends, in Karthus vs Ryze matchups, Ryze is the better champion with a much lower win rate, similar champion depth, and a similar amount of utility to help out your team members during team fights.
Karthus is a terribly counter to Ryze. Focus your gameplay on keeping up your gold income and taking out objectives. If you can do that, you should do very well as Karthus against Ryze.
If you would like to truly master Karthus in order to counter Ryze during both the laning and mid / late game phases of League of Legends, you should continue reading to pick up a few extra tricks and insights into this matchup. If you mind the build and suggestions presented here, you will increase your win rate by a lot and be closer to League of Legends pro players.
Karthus often picks up less CS as Ryze. Champions who on average don't take many minion kills usualy don't need much CS to be effective, such as sup champs. They are able to scale well off of their abilities and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, typically need many items to be effective. In either case, try to surpass the values displayed on this page to do well.
The most important items to focus on in your Karthus versus Ryze build include Rabadon's Deathcap, Malignance, and Liandry's Torment. When Karthus used at least these three items in his build, he performed significantly better vs Ryze than with most other common builds. In fact, Karthus had an average winrate of 46.6% battling Ryze with this build.
To have the highest chance of annihilating Ryze as Karthus, you should equip the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Of all the rune sets players chose for Karthus vs Ryze face-offs, this combo of runes yielded the greatest win rate. Notably, these runes provided a 46.6% win rate overall.
By default, tips, stats, and builds on how to beat Ryze as Karthus are presented for every ranked division. To filter the statistics and builds to a distinct division, you may use the selection menu earlier in the counter matchup guide.