Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
When Rek'Sai is near, she can see the position of you and your allies, but only if you're moving.
If you see one of Rek'Sai's tunnels, briefly stand on one of the entrances to destroy it.
Rek'Sai's Furious Bite gains damage as she builds Fury. Be very careful around her when her Fury is full.
The stats shown here underscore some strategic Karthus vs. Rek'Sai counter stats that can help us appreciate the differences and similarities between this pair of champs. For instance, Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is more than Rek'Sai’s KDA ratio of NaN, highlighting that Karthus may be more central to his team's team fighting capacity than Rek'Sai..
Karthus typically has a similar longest killing spree as his foe does. Typically, he takes less damage than Rek'Sai. This is usually reflective of different amounts of tankyness; however, it can also hint that the one champion has less agility and thus is unable to kite away from further damage when poked or engaged.
Both League of Legends champions are great champions. Both have their strengths, weaknesses, and counters. In the game's current meta, Karthus usually loses when trying to fight Rek'Sai, with a 47.7% win rate. As a result, Karthus makes a bad counter to Rek'Sai.
While Karthus does have a lower winrate than Rek'Sai, when on opposite teams, Karthus also has a much greater learning curve that makes him a more challenging champ to learn and master. You may get destroyed when picking Karthus into Rek'Saias his relative depth means you may not be able to reach his full potential without a lot of practice beforehand.
Furthermore, Karthus has some amount of utility and CC, a similar amount to Rek'Sai. This often makes her just as valuable during team fights, especially when facing champions with a ton of burst damage.
While there isn't one best champion overall in League of Legends, in Karthus vs Rek'Sai matchups, Rek'Sai is the better champ with a lower win rate, more champion depth, and a similar amount of utility to help out your allied champions during late stage team fights.
Karthus is a terribly counter for Rek'Sai. You will do well by focussing your actions on maximizing your CS and destroying objectives. If you are able to do that, you should be able to stand on your own as Karthus against Rek'Sai.
If you would like to truly master Karthus in order to counter Rek'Sai during both the laning and mid / late game phases of League of Legends, you should continue reading to learn a few extra lessons on this matchup. If you pay attention to the build and suggestions presented above, you will grow your win rate significantly and be that much closer to League of Legends pro players.
Karthus usually accumulates more CS compared to Rek'Sai. Champions who typically don't take much CS typically don't have to have much CS to be valuable teammates, such as support champions. They are able to scale properly off of their skills, stats, and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, typically require many items to be effective. In either situation, try to do better than the numbers reported on this page to do well.
The most crucial items to use in your Karthus versus Rek'Sai build include Rabadon's Deathcap, Malignance, and Liandry's Torment. When Karthus used at least these three pieces in his build, he did much better against Rek'Sai than with most other typical builds. In fact, Karthus had an average winrate of 47.7% when countering Rek'Sai with this counter build.
To have the best likelihood of vanquishing Rek'Sai as Karthus, you should take the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Of all the rune builds players chose for Karthus vs Rek'Sai face-offs, this sequence of runes resulted in the best win rate. Moreover, these runes provided a 47.7% winrate overall.
If you would like to get Karthus versus Rek'Sai tips and counter builds for a a distinct division rank, feel free to select one from the selection menu above. If viewing for the first time, the statistics and guides shown are computed using every round played with these champs.