Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Miss Fortune's speed boost is removed if she is damaged by an enemy.
Miss Fortune is easy to kill if you can reach her; target her first in team fights.
The stats provided here highlight several significant Karthus against Miss Fortune matchup statistics that may help you interpret the distinctions between this pair of champions. For instance, Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is more than Miss Fortune’s KDA ratio of NaN, demonstrating that Karthus may be more central to his team's team fighting capacity than Miss Fortune..
Karthus often has a slightly smaller longest kill spree than his foe does. Typically, he takes more damage than Miss Fortune. This often reflects differing health capacities, but it can also imply that the one champion has less agility and thus is unable to flee from additional damage when engaged or poked.
Both League of Legends champions are great. Both have their strengths, weaknesses, and counters. In the game's current meta, Karthus usually loses when trying to fight Miss Fortune, with a 43.8% win rate. As a result, Karthus makes a bad counter for Miss Fortune.
While Karthus does have a much lower win rate than Miss Fortune, when on opposite teams, Karthus also has a much greater level of difficulty that makes him a more challenging character to learn and master. You should expect to face a difficult match when picking Karthus into Miss Fortuneas his relative depth means that you may not be able to unleash his full potential without a lot of practice beforehand.
Furthermore, Karthus has some amount of CC and other utility, a similar amount to Miss Fortune. This makes her just as valuable during team fights, especially when fighting champions with a lot of burst damage.
While there is not a single best champion for every situation in League of Legends, in Karthus vs Miss Fortune matchups, Miss Fortune is the better champion with a much lower win rate, more champion depth, and a similar amount of utility to help out your allies during teamfights.
Karthus is a garbage counter for Miss Fortune. You will do well by focussing your play on maximizing your gold and cs and destroying objectives. If you do that, you should be able to stand on your own as Karthus against Miss Fortune.
If you would like to truly master Karthus to counter Miss Fortune during both the early game and mid / late game phases of League of Legends, you should continue reading to pick up a few extra tricks and insights into this matchup. If you pay attention to the build and suggestions presented above, you will grow your win rate by a lot and be closer to League of Legends pro players.
Karthus usually racks up less CS relative to Miss Fortune. Champs who on average don't acquire many minion kills usualy don't have to have much CS to be effective, such as supports. They are able to scale properly off of their abilities and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, often require several high cost items to be effective. In either situation, try to do better than the values displayed on this page to do well.
The most crucial items to focus on in your Karthus versus Miss Fortune build include Rabadon's Deathcap, Malignance, and Stormsurge. When Karthus bought at least these three items in his build, he did much better against Miss Fortune than with many other commonly used builds. In fact, Karthus boasted an average win rate of 43.8% when countering Miss Fortune with these items in his kit.
To have the highest chance of annihilating Miss Fortune as Karthus, you should equip the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Presence of Mind, and Last Stand runes from the Domination and Precision rune sets. Out of all the runes players picked for Karthus vs Miss Fortune LoL games, this order of runes yielded the best win rate. In fact, these runes provided a 43.8% winrate overall.
By default, tips, statistics, and builds on how to beat Miss Fortune as Karthus are given for all skill levels combined. If you would like to narrow the stats and builds to an individual player tier, you should use the selection menu located above.