Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Gwen must hit something to recast her Ultimate, try to evade her between casts.
Gwen needs to attack a few times to set up her damage, so try to get the jump on her.
Gwen's Hallowed Mist shroud will only follow her once, after that it will dissipate when she leaves.
The stat comparisons shown on this page underscore some important Karthus against Gwen counter stats that may help us understand the distinctions between the pair. As an example, Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Gwen’s ratio of NaN, demonstrating that Karthus may be more central to his team's team fighting potential than Gwen. This observation is largely caused by the differences in assists.
Karthus typically has a similar longest kill spree as his enemy does. Typically, he receives less damage than Gwen. This commonly reflects differing health capacities, but it can also show that the champion with higher HP has less mobility and thus is unable to kite away from further harm when poked or engaged.
Both League champions are great. Both champs have their strengths, weaknesses, and counters. In the game's current meta, Karthus usually loses when trying to fight Gwen, with a 47.1% win rate. As a result, Karthus makes a bad counter for Gwen.
While Karthus does have a lower win rate than Gwen, when they face off with one another, Karthus also has a greater difficulty level that makes him a more difficult character to learn and master. You should expect to face a difficult match when picking Karthus into Gwenas his relative depth means you may not be able to reach his full potential without a significant amount of practice beforehand.
Additionally, Karthus has some amount of CC and other utility, a similar amount to Gwen. This often makes her just as valuable during teamfights, especially when trying to counter champions with a lot of burst damage.
While there isn't one best champion overall in League of Legends, in Karthus vs Gwen matchups, Gwen is the better champion with a lower win rate, more champion depth, and a similar amount of utility to help out your team members during team fights.
Karthus is a garbage counter to Gwen. You will do well by focussing your tactics on increasing your CS and destroying objectives. If you can do that, you should hold your own as Karthus against Gwen.
If you would like to truly master Karthus in order to counter Gwen during both the early game and mid / late game phases of League of Legends, you should continue reading to gather a few extra tricks and insights into this matchup. If you mind the build and suggestions shown here, you will grow your win rate significantly and be that much closer to League of Legends pro players.
Karthus on average gets less CS as Gwen. Champs who typically don't acquire much CS typically don't have to have much CS to be effective, such as support champions. These kinds of champions are capable of scaling properly off of their skills, stats, and first items alone. Yet, champs with a lot of CS, such as hyper-carries, often have to have a lot of items to be effective. In either situation, try to do better than the values reported here to do well.
The most important items to have in your Karthus versus Gwen build include Rabadon's Deathcap, Shadowflame, and Liandry's Torment. When Karthus bought at least these three pieces in his build, he did a lot better when fighting Gwen than with most other commonly used counter builds. In fact, Karthus had an average winrate of 47.1% when playing against Gwen with these items in his kit.
To have the greatest chance of coming out on top against Gwen as Karthus, Karthus players should use the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Out of all the rune combinations that we analyzed for Karthus vs Gwen matchups, this sequence of runes resulted in the highest win rate. In fact, these runes provided a 47.1% winrate overall.
If you would like to view Karthus versus Gwen tips and counter builds for a a particular division, feel free to select one from the selection menu shown above. By default, the stats and strategies given are calculated using every match run with both champions.