Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Be wary of Cassiopeia's damage potential with Twin Fang when she has you poisoned.
Turn away from Cassiopeia when she is casting Petrifying Gaze to get slowed instead of stunned.
The stats provided here feature some strategic Karthus versus Cassiopeia counter stats that can help you appreciate the differences and similarities between the pair. Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Cassiopeia’s KDA ratio of NaN, demonstrating that Karthus may be more central to his team's team fighting capacity than Cassiopeia..
Karthus normally has a similar longest kill spree as his counter does. On average, he receives a similar amount of damage to Cassiopeia. This commonly reflects different amounts of tankyness, but it can also imply that the one champ has less agility and thus is unable to kite away from further damage when poked or engaged.
Both League champs are great champions. Both champs have their strengths, weaknesses, and counters. In the game's current meta, Karthus usually loses when facing off against Cassiopeia, with a 45.6% win rate. As a result, Karthus makes a poor counter for Cassiopeia.
While Karthus does have a much lower winrate than Cassiopeia, when facing one another, Karthus also has a lower learning curve that makes him a less complex champ to develop with. You may get destroyed when picking Karthus into Cassiopeiaas his relative depth means that you may not be able to reach his full potential without a significant amount of practice beforehand.
Furthermore, Karthus also has some amount of utility and CC, a similar amount to Cassiopeia. This often makes her just as valuable during teamfights, especially when trying to counter champions with a lot of burst damage.
While there isn't a single best champion overall in League of Legends, in Karthus vs Cassiopeia matchups, Cassiopeia is the better champ with a much lower win rate, less champion complexity, and a similar amount of utility to help out your allied champions during team fights.
Karthus is a garbage counter for Cassiopeia. You will do well by focussing your tactics on maximizing your gold and cs and destroying objectives. If you can do that, you should hold your own as Karthus against Cassiopeia.
If you would like to truly master Karthus to counter Cassiopeia during both the laning and mid / late game phases of League of Legends, you should keep reading to gather a few extra tips and tricks for this matchup. If you listen to the build and tips shown above, you will grow your win rate by a lot and be closer to League of Legends pro players.
Karthus often accumulates less CS as Cassiopeia. Champions who on average don't get many minion kills typically don't need much CS to be effective, such as sup champs. They are able to scale well off of their skills, stats, and first items alone. Yet, champions with a lot of CS, such as hyper-carries, usually have to have many items to be effective. In either situation, try to do better than the numbers displayed on this page to do well.
The top items to have in your Karthus versus Cassiopeia build include Malignance, Stormsurge, and Liandry's Torment. When Karthus bought at least these three pieces in his build, he did much better when fighting Cassiopeia than with most other typical counter builds. In fact, Karthus boasted an average winrate of 45.6% when countering Cassiopeia with this build.
To have the best chance of defeating Cassiopeia as Karthus, Karthus players should use the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Of all the rune sets players chose for Karthus vs Cassiopeia counter picks, this mixture of runes resulted in the highest win rate. In fact, these runes gave a 45.6% win rate overall.
By default, tips, stats, and builds on how to beat Cassiopeia as Karthus are displayed for all ranked divisions combined. If you want to narrow the statistics and builds to a distinct rank, you should use the selection menu above.