Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Annie's summoned bear, Tibbers, burns opposing units around himself. Try to keep your distance from him after he's been summoned.
Keep an eye out for a white, swirling power around Annie. It means she's ready to unleash her stun.
Summoner Smite can be used to help take down Tibbers.
The stat comparisons shown here emphasize some strategic Karthus versus Annie matchup stats that can help us interpret the distinctions between the two. As an example, Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Annie’s KDA ratio of NaN, demonstrating that Karthus may be more central to his team's team fighting capability than Annie..
Karthus typically has a similar longest killing spree as his enemy does. Commonly, he takes more damage than Annie. This commonly reflects differing health capacities, yet it can also imply that the one champion has less mobility and thus is unable to kite away from additional damage when poked or engaged.
Both League of Legends champions are great champions. Both have their pros and cons. In the game's current meta, Karthus usually loses when taking on Annie, with a 47.9% win rate. Therefore, Karthus makes a poor counter to Annie.
While Karthus does have a lower win rate than Annie, when facing one another, Karthus also has a greater learning curve that makes him a more difficult champion to learn. You should expect to face a difficult match when picking Karthus into Annieas his relative depth means you may not be able to reach his full potential without a lot of practice beforehand.
Furthermore, Karthus has some amount of CC and other utility, a similar amount to Annie. This often makes her just as valuable during team fights, especially when fighting champions with a ton of burst damage.
While there is not a single best champion in League of Legends, in Karthus vs Annie matchups, Annie is the better champion with a lower win rate, more champion depth, and a similar amount of utility to help out your allies during late stage team fights.
Karthus is a garbage counter for Annie. Make sure you focus your gameplay on maximizing your gold income and clearing objectives. If you are able to do that, you should hold your own as Karthus against Annie.
To learn all of the intricacies of Karthus to counter Annie during both the early game and mid / late game phases of League of Legends, you should continue reading to gather a few extra tips and tricks for this matchup. If you listen to the build and tips shown above, you will increase your win rate significantly and be that much closer to League of Legends pro players.
Karthus often picks up less CS relative to Annie. Champions who typically don't earn much CS often don't need much CS to be valuable teammates, such as supports. They are capable of scaling well off of their skills, stats, and first items alone. Yet, champs with a lot of CS, such as hyper-carries, typically have to have several high cost items to be effective. In either situation, try to exceed the values shown on this page to do well.
The top items to have in your Karthus versus Annie build include Rabadon's Deathcap, Malignance, and Liandry's Torment. When Karthus incorporated at least these three items in his build, he did significantly better vs Annie than with many other commonly used item sets. In fact, Karthus had an average winrate of 47.9% when countering Annie with this build.
To have the best probability of crushing Annie as Karthus, you should equip the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Gathering Storm, and Transcendence runes from the Domination and Sorcery rune sets. Out of all the rune combinations players chose for Karthus vs Annie LoL games, this sequence of runes resulted in the highest win rate. In fact, these runes averaged a 47.9% winrate overall.
If you need to get Karthus x Annie tips and counter builds for a a particular skill level, feel free to choose one from the selection menu shown above. By default, the statistics and guides given are calculated using every game finished with these champions.