Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stat comparisons provided here show several influential Kai'Sa versus Vayne matchup stats that may help us interpret the distinctions between the two. Kai'Sa’s KDA ratio ([kills + assists] / deaths) of NaN is more than Vayne’s ratio of NaN, indicating that Kai'Sa may be more central to her team's team fighting potential than Vayne..
Kai'Sa usually has a similar longest kill spree as her opponent does. Commonly, she takes a similar amount of damage to Vayne. This commonly reflects different amounts of tankyness, yet it can also illustrate that the champion with more health has less mobility and thus is not able to kite away from additional damage when engaged or poked.
Both League champs are great. Both have their strengths, weaknesses, and counters. In League's current meta, Kai'Sa usually loses when trying to fight Vayne, with a 45.8% win rate. As a result, Kai'Sa makes a bad counter to Vayne.
While Kai'Sa does have a much lower win rate than Vayne, when facing one another, Kai'Sa also has a lower difficulty level that makes her a less difficult champion to pick up and master. You may get destroyed when picking Kai'Sa into Vayne.
Moreover, Kai'Sa has only a small amount of utility and CC, a similar amount to Vayne. This makes her just as valuable during team fights, especially when fighting champions with a lot of burst damage.
While there isn't a single best champion overall in League of Legends, in Kai'Sa vs Vayne matchups, Vayne is the better champ with a much lower win rate, less champion complexity, and a similar amount of utility to help out your team members during teamfights.
Kai'Sa is a terribly counter for Vayne. Make sure you focus your tactics on increasing your gold income and clearing objectives. If you can do that, you should do very well as Kai'Sa against Vayne.
If you would like to learn all of the intricacies of Kai'Sa to counter Vayne during both the lane and mid / late game phases of League of Legends, you should keep reading to pick up a few extra tricks and insights into this matchup. If you mind the build and stats shown above, you will grow your win rate by a lot and be that much closer to League of Legends pro players.
Kai'Sa most often picks up a similar amount of CS relative to Vayne. Champions who on average don't earn many minion kills often don't have to have much CS to be valuable teammates, such as support champions. These kinds of champions are able to scale well off of their abilities and first items alone. Yet, champions with a lot of CS, such as hyper-carries, often have to have a lot of items to be effective. In either case, try to exceed the values shown on this page to do well.
The best items to use in your Kai'Sa versus Vayne build include Muramana, Rabadon's Deathcap, and Stormsurge. When Kai'Sa included at least these three pieces in her build, she performed a lot better when facing Vayne than with many other typical builds. In fact, Kai'Sa had an average winrate of 45.8% battling Vayne with these items in her kit.
To have the highest likelihood of beating Vayne as Kai'Sa, you should equip the Hail of Blades, Taste of Blood, Eyeball Collection, Treasure Hunter, Biscuit Delivery, and Magical Footwear runes from the Domination and Inspiration rune sets. Out of all the rune combinations we have analyed for Kai'Sa vs Vayne counterpicks, this sequence of runes resulted in the greatest win rate. In fact, these runes gave a 45.8% winrate overall.
If you want to view Kai'Sa vs Vayne tips and counter stats for a a specific division, please choose one from the selection menu displayed above. By default, the statistics and strategies given are computed using every match with data with both champions.