Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
Zilean is fragile if a team focuses on him, but otherwise he's very difficult to kill. Commit to killing him as a team.
If you're able to match Zilean's speed, it can sometimes be beneficial to wait until his ultimate has faded before landing the killing blow.
The stats shown here show some significant Cassiopeia versus Zilean counter stats that can help us realize the distinctions between the pair. As an example, Cassiopeia’s KDA ratio ([kills + assists] / deaths) of NaN is more than Zilean’s KDA ratio of NaN, indicating that Cassiopeia may be more central to her team's team fighting effectiveness than Zilean. This observation is in large part a result of the difference in kills.
Cassiopeia usually has a much larger longest killing spree than her foe does. Commonly, she takes more damage than Zilean. This commonly reflects different amounts of tankyness, but it can also indicate that the champ with more HP has less agility and thus is not able to escape additional harm when engaged or poked.
Both LoL champs are great champions. Both champs have their strengths, weaknesses, and counters. In League's current meta, Cassiopeia usually fairs equally well when facing off against Zilean, with a 49.4% win rate. Therefore, Cassiopeia makes an ok counter for Zilean.
While Cassiopeia does have a lower winrate compared to Zilean, when facing one another, Cassiopeia also has a much greater level of difficulty that makes her a more difficult character to develop with. You still need to be cautious when picking Cassiopeia into Zileanas her relative depth means you may not be able to reach her full potential without a lot of practice beforehand.
Furthermore, Cassiopeia has a good amount of CC and other utility, a similar amount to Zilean. This makes her just as valuable during team fights, especially when facing champions with a ton of burst damage.
While there isn't a single best champion overall in League of Legends, in Cassiopeia vs Zilean matchups, Zilean is the better champion with a similar win rate, more champion depth, and a similar amount of utility to help out your teammates during team fights.
Cassiopeia is a somewhat poor counter to Zilean. You will do well by focussing your play on increasing your gold income and clearing objectives. If you can do that, you should do very well as Cassiopeia against Zilean.
If you would like to truly master Cassiopeia in order to counter Zilean during both the laning and mid / late game phases of League of Legends, you should continue reading to learn a few extra tricks and insights into this matchup. If you mind the build and stats presented above, you will increase your win rate by a lot and be that much closer to League of Legends pro players.
Cassiopeia typically accumulates much more CS as Zilean. Champs who typically don't earn much CS typically don't require much CS to be effective, such as support champions. These kinds of champions are capable of scaling well off of their abilities and first items alone. Yet, champions with large amounts of CS, such as hyper-carries, usually require several high cost items to be effective. In either situation, try to do better than the values shown here to do well.
The most crucial items to focus on in your Cassiopeia versus Zilean build consist of Seraph's Embrace, Rylai's Crystal Scepter, and Liandry's Torment. When Cassiopeia used at least these three items in her build, she performed significantly better versus Zilean than with many other commonly used builds. In fact, Cassiopeia had an average winrate of 49.4% battling Zilean with these items in her kit.
To have the best probability of coming out on top against Zilean as Cassiopeia, Cassiopeia players should use the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Manaflow Band, and Transcendence runes from the Precision and Sorcery rune sets. Of all the rune sets players chose for Cassiopeia vs Zilean counters, this mixture of runes yielded the highest win rate. Moreover, these runes averaged a 49.4% win rate overall.
By default, tips, stats, and builds on how to beat Zilean as Cassiopeia are displayed for all skill levels, merged. If you want to narrow the stats and builds to an individual rank, you may use the selection menu earlier on the page.