Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
Items that counter Health stacking, such as Liandry's Torment and Blade of the Ruined King, are very effective against Vladimir.
Making Vladimir use Sanguine Pool at the start of a fight will maximize the Health cost of the ability to him.
Try to take Vladimir down before Hemoplague detonates, as it will heal him for each afflicted enemy Champion.
The stats shown on this page underscore some vital Cassiopeia against Vladimir matchup statistics that may help you explain the distinctions between the two. Cassiopeia’s KDA ratio ([kills + assists] / deaths) of NaN is more than Vladimir’s ratio of NaN, indicating that Cassiopeia may be more central to her team's team fighting capability than Vladimir..
Cassiopeia often has a similar longest killing spree as her opponent does. Typically, she receives less damage than Vladimir. This commonly reflects different amounts of tankyness; however, it can also indicate that the one champion has less agility and thus is not able to kite away from additional damage when engaged or poked.
Both League of Legends champions are great. Both champs have their strengths, weaknesses, and counters. In League's current meta, Cassiopeia usually loses when trying to fight Vladimir, with a 48.0% win rate. Thus, Cassiopeia makes a bad counter to Vladimir.
While Cassiopeia does have a lower winrate than Vladimir, when facing one another, Cassiopeia also has a much greater level of difficulty that makes her a more difficult champ to pick up and master. You should be very concerned when picking Cassiopeia into Vladimiras her relative depth means that you may not be able to unleash her full potential without a lot of practice beforehand.
Additionally, Cassiopeia has a good amount of utility and CC, a similar amount to Vladimir. This makes her just as valuable during teamfights, especially when facing champions with a lot of burst damage.
While there is not a single best champion in League of Legends, in Cassiopeia vs Vladimir matchups, Vladimir is the better champ with a lower win rate, more champion depth, and a similar amount of utility to help out your allied champions during late stage team fights.
Cassiopeia is a terribly counter to Vladimir. You will do well by focussing your play on increasing your gold and cs and destroying objectives. If you can do that, you should hold your own as Cassiopeia against Vladimir.
If you would like to truly master Cassiopeia in order to counter Vladimir during both the laning and mid / late game phases of League of Legends, you should keep reading to pick up a few extra tips and tricks for this matchup. If you listen to the build and stats presented above, you should grow your win rate significantly and be closer to League of Legends pro players.
Cassiopeia typically gets a similar amount of CS relative to Vladimir. Champs who on average don't earn many minion kills typically don't have to have much CS to be effective, such as sup champs. They are able to scale properly off of their skills, stats, and first items alone. Yet, champions with a lot of CS, such as hyper-carries, typically have to have many items to be effective. In either case, try to do better than the numbers displayed on this page to do well.
The most important items to prioritize in your Cassiopeia versus Vladimir build include Seraph's Embrace, Cosmic Drive, and Rod of Ages. When Cassiopeia incorporated at least these three pieces in her build, she did a lot better countering Vladimir than with most other typical counter builds. In fact, Cassiopeia had an average win rate of 48.0% when playing against Vladimir with this counter build.
To have the highest probability of coming out on top against Vladimir as Cassiopeia, Cassiopeia players should equip the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Manaflow Band, and Transcendence runes from the Precision and Sorcery rune sets. Out of all the rune sets we have analyed for Cassiopeia vs Vladimir fights, this composite of runes yielded the greatest win rate. In fact, these runes provided a 48.0% win rate overall.
By default, tips, statistics, and builds on how to beat Vladimir as Cassiopeia are displayed for all ranked divisions. If you would like to scope the statistics and builds to a distinct skill level, you can use the selection menu earlier in the counter matchup guide.