Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stat comparisons shown here underscore some critical Cassiopeia against Vayne matchup stats that may help us explain the distinctions between this set of champions. For instance, Cassiopeia’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Vayne’s KDA ratio of NaN, demonstrating that Cassiopeia may be more central to her team's team fighting effectiveness than Vayne..
Cassiopeia typically has a similar longest killing spree as her opponent does. On average, she receives more damage than Vayne. This is usually reflective of differing health capacities, yet it can also indicate that the champion with higher health has less agility and thus is not able to escape further harm when engaged or poked.
Both LoL champs are great champions. Both have their pros and cons. In the game's current meta, Cassiopeia usually wins when playing against Vayne, with a 51.4% win rate. Therefore, Cassiopeia makes a good counter to Vayne.
While Cassiopeia does have a higher win rate compared to Vayne, when on opposite teams, Cassiopeia also has a greater learning curve that makes her a more challenging champion to develop with. You still need to be cautious when picking Cassiopeia into Vayneas her relative depth means that you may not be able to reach her full potential without a lot of practice beforehand.
Furthermore, Cassiopeia has a good amount of CC and other utility, a similar amount to Vayne. This often makes her just as valuable during teamfights, especially when trying to counter champions with a ton of burst damage.
While there is not a single best champion in League of Legends, in Cassiopeia vs Vayne matchups, Cassiopeia is the better champion with a higher win rate, more champion depth, and a similar amount of utility to help out your allied champions during late stage team fights.
Cassiopeia is a decent counter for Vayne. Focus your gameplay on maximizing your gold and cs and destroying objectives. If you can do that, you should be able to stand on your own as Cassiopeia against Vayne.
To truly master Cassiopeia in order to counter Vayne during both the laning and mid / late game phases of League of Legends, you should continue reading to pick up a few extra tricks and insights into this matchup. If you pay attention to the build and tips displayed above, you will increase your win rate significantly and be closer to League of Legends pro players.
Cassiopeia often racks up a similar amount of CS as Vayne. Champs who typically don't acquire much CS usualy don't have to have much CS to be valuable teammates, such as supports. They are able to scale properly off of their skills, stats, and first items alone. Yet, champs with a lot of CS, such as hyper-carries, typically have to have several high cost items to be effective. In either case, try to exceed the values shown on this page to do well.
The top items to focus on in your Cassiopeia versus Vayne build include Seraph's Embrace, Zhonya's Hourglass, and Rod of Ages. When Cassiopeia combined at least these three pieces in her build, she performed much better vs Vayne than with many other common counter builds. In fact, Cassiopeia boasted an average winrate of 51.4% when countering Vayne with these items in her kit.
To have the best likelihood of beating Vayne as Cassiopeia, you should equip the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Manaflow Band, and Transcendence runes from the Precision and Sorcery rune sets. Of all the rune sets players used for Cassiopeia vs Vayne fights, this blending of runes yielded the greatest win rate. Notably, these runes averaged a 51.4% win rate overall.
If you would like to see Cassiopeia versus Vayne tips and builds for a a distinct skill level, feel free to select one from the selection menu shown above. If viewing for the first time, the statistics and guides given are calculated using all rounds finished with these champions.