Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The stats provided here show some influential Cassiopeia vs. Seraphine matchup stats that may help you understand the distinctions between these two champs. For instance, Cassiopeia’s KDA ratio ([kills + assists] / deaths) of NaN is more than Seraphine’s KDA ratio of NaN, highlighting that Cassiopeia may be more central to her team's team fighting effectiveness than Seraphine. This observation is largely a result of the difference in kills.
Cassiopeia usually has a slightly larger longest kill spree than her opponent does. Commonly, she receives more damage than Seraphine. This often reflects differing health capacities; however, it can also show that the champ with higher health has less agility and thus is unable to flee from additional harm when engaged or poked.
Both League of Legends champions are great champions. Both have their strengths, weaknesses, and counters. In the game's current meta, Cassiopeia usually fairs equally well when trying to fight Seraphine, with a 49.6% win rate. As a result, Cassiopeia makes an ok counter to Seraphine.
While Cassiopeia does have a lower winrate compared to Seraphine, when they face off with one another, Cassiopeia also has a much greater level of difficulty that makes her a more time consuming champ to pick up and master. You should be careful when picking Cassiopeia into Seraphineas her relative depth means that you may not be able to unleash her full potential without a lot of practice beforehand.
Furthermore, Cassiopeia also has a good amount of CC and other utility, a similar amount to Seraphine. This makes her just as valuable during team fights, especially when trying to counter champions with a lot of burst damage.
While there isn't a single best champion overall in League of Legends, in Cassiopeia vs Seraphine matchups, Seraphine is the better champion with a similar win rate, more champion depth, and a similar amount of utility to help out your team members during team fights.
Cassiopeia is a somewhat poor counter to Seraphine. Focus your gameplay on keeping up your gold income and taking out objectives. If you can do that, you should hold your own as Cassiopeia against Seraphine.
If you would like to truly master Cassiopeia to counter Seraphine during both the laning and mid / late game phases of League of Legends, you should keep reading to gather a few extra lessons on this matchup. If you listen to the build and stats displayed above, you will increase your win rate by a lot and be that much closer to League of Legends pro players.
Cassiopeia most often picks up more CS as Seraphine. Champions who on average don't take much CS typically don't have to have much CS to be effective, such as support champions. They are capable of scaling well off of their abilities and first items alone. Yet, champions with large amounts of CS, such as hyper-carries, usually require a lot of items to be effective. In either situation, try to surpass the values reported on this page to do well.
The best items to prioritize in your Cassiopeia versus Seraphine build consist of Seraph's Embrace, Rylai's Crystal Scepter, and Cosmic Drive. When Cassiopeia incorporated at least these three items in her build, she performed a lot better when facing Seraphine than with many other common item sets. In fact, Cassiopeia boasted an average win rate of 49.6% when playing against Seraphine with this build.
To have the highest likelihood of annihilating Seraphine as Cassiopeia, Cassiopeia players should take the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Manaflow Band, and Transcendence runes from the Precision and Sorcery rune sets. Out of all the rune sets that we analyzed for Cassiopeia vs Seraphine clashes, this sequence of runes resulted in the greatest win rate. Moreover, these runes averaged a 49.6% win rate overall.
If you want to get Cassiopeia vs Seraphine tips and builds for a a specific division rank, please choose one from the selection menu provided above. At first, the statistics and guides given are calculated using all rounds with data with these champions.