Use the CC from your abilities to land both of your Precision Protocol attacks on enemies.
Try waiting until the other team is distracted with fighting your team, and use Hookshot to pick off vulnerable targets.
Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stat comparisons shown on this page highlight several significant Camille vs. Vayne matchup stats that can help you interpret the differences and similarities between this set of champions. For instance, Camille’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Vayne’s ratio of NaN, demonstrating that Camille may be more central to her team's team fighting capacity than Vayne..
Camille usually has a slightly smaller longest kill spree than her counter does. On average, she receives more damage than Vayne. This typically indicates different amounts of tankyness; however, it can also imply that the champ with higher health has less agility and thus is not able to flee from further damage when engaged or poked.
Both League of Legends champs are great. Both champs have their pros and cons. In League's current meta, Camille usually loses when playing against Vayne, with a 46.5% win rate. Therefore, Camille makes a poor counter for Vayne.
While Camille does have a lower winrate compared to Vayne, when they face off with one another, Camille also has a much lower difficulty level that makes her a less complex character to learn. You should be very concerned when picking Camille into Vayne.
Moreover, Camille also has only a small amount of CC and other utility, a similar amount to Vayne. This makes her just as valuable during team fights, especially when fighting champions with a lot of burst damage.
While there isn't one best champion in League of Legends, in Camille vs Vayne matchups, Vayne is the better champ with a much lower win rate, less champion complexity, and a similar amount of utility to help out your team members during teamfights.
Camille is a terribly counter for Vayne. You will do well by focussing your actions on maximizing your gold and cs and clearing objectives. If you can do that, you should do very well as Camille against Vayne.
To learn all of the intricacies of Camille to counter Vayne during both the lane and mid / late game phases of League of Legends, you should continue reading to pick up a few extra tips and tricks for this matchup. If you listen to the build and suggestions presented above, you will increase your win rate significantly and be closer to League of Legends pro players.
Camille often accumulates a similar amount of CS as Vayne. Champs who on average don't earn many minion kills often don't require much CS to be effective, such as sup champs. They are capable of scaling well off of their skills, stats, and first items alone. Yet, champs with a lot of CS, such as hyper-carries, often have to have a lot of items to be effective. In either case, try to surpass the values reported on this page to do well.
The top items to have in your Camille versus Vayne build include Ravenous Hydra, Trinity Force, and Sundered Sky. When Camille included at least these three pieces in her build, she did a lot better when facing Vayne than with most other common item sets. In fact, Camille boasted an average win rate of 46.5% battling Vayne with these items in her kit.
To have the greatest probability of annihilating Vayne as Camille, you should take the Grasp of the Undying, Shield Bash, Bone Plating, Unflinching, Magical Footwear, and Biscuit Delivery runes from the Resolve and Inspiration rune sets. Of all the runes players chose for Camille vs Vayne counters, this composite of runes resulted in the highest win rate. In fact, these runes averaged a 46.5% winrate overall.
If you need to see Camille vs Vayne tips and counter builds for a a particular skill level, feel free to select one from the selection menu displayed above. By default, the stats and strategies displayed are computed using every game run with these champs.