Use the CC from your abilities to land both of your Precision Protocol attacks on enemies.
Try waiting until the other team is distracted with fighting your team, and use Hookshot to pick off vulnerable targets.
Karthus can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.
The stats shown here clarify some influential Camille versus Karthus matchup statistics that can help you realize the distinctions between the pair. Camille’s KDA ratio ([kills + assists] / deaths) of NaN is better than Karthus’s KDA ratio of NaN, demonstrating that Camille may be more central to her team's team fighting potential than Karthus..
Camille often has a similar longest killing spree as her foe does. Commonly, she receives more damage than Karthus. This often reflects differing health capacities; however, it can also imply that the one champion has less agility and thus is not able to kite away from further damage when engaged or poked.
Both League champs are great champions. Both have their pros and cons. In the game's current meta, Camille usually wins when taking on Karthus, with a 53.4% win rate. Thus, Camille makes a great counter for Karthus.
While Camille does have a higher winrate compared to Karthus, when on opposite teams, Camille also has a lower difficulty level that makes her a less time consuming character to pick up and master. You should be be fine when picking Camille into Karthus.
Furthermore, Camille also has almost no amount of CC and other utility, a similar amount to Karthus. This makes her just as valuable during teamfights, especially when facing champions with a lot of burst damage.
While there isn't a single best champion for every situation in League of Legends, in Camille vs Karthus matchups, Camille is the better champ with a noticably higher win rate, less champion complexity, and a similar amount of utility to help out your allied champions during team fights.
Camille is a great counter to Karthus. Make sure you focus your gameplay on keeping up your gold and cs and destroying objectives. If you can do that, you should be able to stand on your own as Camille against Karthus.
If you would like to truly master Camille in order to counter Karthus during both the lane and mid / late game phases of League of Legends, you should continue reading to pick up a few extra tricks and insights into this matchup. If you mind the build and stats shown here, you should increase your win rate by a lot and be that much closer to League of Legends pro players.
Camille on average gets more CS relative to Karthus. Champions who typically don't acquire much CS typically don't need much CS to be effective, such as sup champs. They are able to scale properly off of their skills, stats, and first items alone. Yet, champions with a lot of CS, such as hyper-carries, typically require a lot of items to be effective. In either situation, try to do better than the numbers displayed on this page to do well.
The most important items to have in your Camille versus Karthus build include Ravenous Hydra, Trinity Force, and Maw of Malmortius. When Camille incorporated at least these three pieces in her build, she performed significantly better against Karthus than with most other common builds. In fact, Camille had an average winrate of 53.4% battling Karthus with these items in her kit.
To have the best likelihood of annihilating Karthus as Camille, Camille players should take the Grasp of the Undying, Shield Bash, Bone Plating, Unflinching, Legend: Alacrity, and Triumph runes from the Resolve and Precision rune sets. Of all the rune combinations players chose for Camille vs Karthus fights, this combo of runes resulted in the greatest win rate. Moreover, these runes gave a 53.4% win rate overall.
By default, tips, stats, and builds on how to beat Karthus as Camille are presented for all ranked divisions. To narrow the stats and builds to an individual skill level, you should use the selection menu located above.