Fire 90 Caliber Net away from the opponent to close the gap or hop over walls.
Avoid using Ace in the Hole in large team melees as it might be blocked by the wrong target.
Make use of her Yordle Snap Traps by placing them pre-emptively to ensure that you'll have one off of cooldown during combat.
Karthus can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.
The stats shown on this page show some influential Caitlyn vs. Karthus counter statistics that may help you figure out the differences and similarities between these two champs. Caitlyn’s KDA ratio ([kills + assists] / deaths) of NaN is more than Karthus’s KDA ratio of NaN, showing that Caitlyn may be more central to her team's team fighting effectiveness than Karthus..
Caitlyn typically has a similar longest kill spree as her counter does. Typically, she receives less damage than Karthus. This typically indicates different amounts of tankyness, but it can also indicate that the one champ has less mobility and thus is unable to flee from further damage when engaged or poked.
Both LoL champs are great. Both have their strengths, weaknesses, and counters. In the game's current meta, Caitlyn usually wins when taking on Karthus, with a 53.5% win rate. Therefore, Caitlyn makes a great counter for Karthus.
While Caitlyn does have a higher win rate than Karthus, when on opposite teams, Caitlyn also has a lower level of difficulty that makes her a less time consuming champion to develop with. You don't need to be too worried when picking Caitlyn into Karthus.
Additionally, Caitlyn also has almost no amount of utility and CC, a similar amount to Karthus. This makes her just as valuable during teamfights, especially when fighting champions with a ton of burst damage.
While there isn't one best champion in League of Legends, in Caitlyn vs Karthus matchups, Caitlyn is the better champ with a noticably higher win rate, less champion complexity, and a similar amount of utility to help out your team members during teamfights.
Caitlyn is a great counter for Karthus. Focus your play on increasing your gold and cs and clearing objectives. If you can do that, you should do very well as Caitlyn against Karthus.
If you would like to truly master Caitlyn in order to counter Karthus during both the lane and mid / late game phases of League of Legends, you should keep reading to pick up a few extra tips and tricks for this matchup. If you mind the build and tips displayed above, you should grow your win rate by a lot and be that much closer to League of Legends pro players.
Caitlyn often picks up more CS relative to Karthus. Champions who on average don't take many minion kills usualy don't require much CS to be valuable teammates, such as supports. These kinds of champions are able to scale well off of their skills, stats, and first items alone. Yet, champions with large amounts of CS, such as hyper-carries, typically need many items to be effective. In either case, try to do better than the numbers shown here to do well.
The best items to use in your Caitlyn versus Karthus build include Lord Dominik's Regards, Bloodthirster, and Rapid Firecannon. When Caitlyn used at least these three items in her build, she did significantly better vs Karthus than with many other common builds. In fact, Caitlyn had an average win rate of 53.5% when countering Karthus with this counter build.
To have the best probability of beating Karthus as Caitlyn, you should equip the First Strike, Magical Footwear, Biscuit Delivery, Cosmic Insight, Absolute Focus, and Gathering Storm runes from the Inspiration and Sorcery rune sets. Out of all the runes players chose for Caitlyn vs Karthus LoL games, this blending of runes resulted in the best win rate. Notably, these runes provided a 53.5% win rate overall.
By default, tips, statistics, and builds on how to beat Karthus as Caitlyn are given for all skill levels combined. If you would like to narrow the stats and builds to a particular division, you should use the selection menu located earlier on the page.