Molten Shield is a good spell to cast to work up to Annie's stun, so sometimes it's beneficial to grab at least 1 rank in it early.
Striking killing blows on minions with Disintegrate enables Annie to farm extremely well early in the game.
Storing a stun for use with her ultimate can turn the tide of a team fight.
Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stats shown here show some valuable Annie versus Vayne matchup stats that can help you figure out the differences and similarities between these two champs. As an example, Annie’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Vayne’s ratio of NaN, highlighting that Annie may be more central to her team's team fighting capability than Vayne..
Annie usually has a similar longest killing spree as her foe does. Commonly, she receives less damage than Vayne. This is usually reflective of different amounts of tankyness, but it can also hint that the champion with more health has less mobility and thus is not able to flee from further damage when poked or engaged.
Both League of Legends champs are great. Both champs have their strengths, weaknesses, and counters. In League's current meta, Annie usually fairs equally well when facing off against Vayne, with a 50.8% win rate. Therefore, Annie makes an ok counter for Vayne.
While Annie does have a higher win rate than Vayne, when facing one another, Annie also has a lower difficulty level that makes her a less complex character to learn and master. You still need to be cautious when picking Annie into Vayne.
Additionally, Annie also has a good amount of CC and other utility, a similar amount to Vayne. This makes her just as valuable during team fights, especially when fighting champions with a lot of burst damage.
While there is not a single best champion for every situation in League of Legends, in Annie vs Vayne matchups, Annie is the better champion with a similar win rate, less champion complexity, and a similar amount of utility to help out your team members during team fights.
Annie is a decent counter for Vayne. You will do well by focussing your strategy on maximizing your CS and destroying objectives. If you can do that, you should do very well as Annie against Vayne.
To truly master Annie to counter Vayne during both the lane and mid / late game phases of League of Legends, you should continue reading to learn a few extra tips and tricks for this matchup. If you listen to the build and tips presented here, you will increase your win rate by a lot and be closer to League of Legends pro players.
Annie usually gets a similar amount of CS as Vayne. Champions who typically don't acquire many minion kills often don't have to have much CS to be valuable teammates, such as support champions. They are capable of scaling properly off of their abilities and first items alone. Yet, champions with a lot of CS, such as hyper-carries, typically require many items to be effective. In either case, try to surpass the numbers reported on this page to do well.
The ideal items to have in your Annie versus Vayne build include Rabadon's Deathcap, Zhonya's Hourglass, and Stormsurge. When Annie included at least these three items in her build, she performed much better vs. Vayne than with most other typical counter builds. In fact, Annie had an average winrate of 50.8% when playing against Vayne with this counter build.
To have the best likelihood of vanquishing Vayne as Annie, you should take the Electrocute, Cheap Shot, Eyeball Collection, Relentless Hunter, Absolute Focus, and Manaflow Band runes from the Domination and Sorcery rune sets. Out of all the runes that we analyzed for Annie vs Vayne clashes, this set of runes yielded the best win rate. In fact, these runes provided a 50.8% win rate overall.
If you want to get Annie vs Vayne tips and counter builds for a a particular rank, please choose one from the selection menu provided above. At first, the statistics and build suggestions shown are calculated using every match with data with both champs.