Akali excels at killing fragile champions. Let your team initiate and then strike at the people in the back.
Twilight Shroud offers safety in even the most dangerous situations. Use that time to save up energy for a quick strike later.
Karthus can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.
The stats shown here emphasize some critical Akali against Karthus counter statistics that can help us explain the differences and similarities between the two. For instance, Akali’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Karthus’s ratio of NaN, showing that Akali may be more central to her team's team fighting capability than Karthus. This observation is largely a result of the difference in kills.
Akali often has a slightly larger longest kill spree than her enemy does. Commonly, she takes a similar amount of damage to Karthus. This commonly reflects differing health capacities, yet it can also show that the one champ has less agility and thus is unable to kite away from further harm when poked or engaged.
Both LoL champs are great. Both have their strengths, weaknesses, and counters. In the game's current meta, Akali usually wins when taking on Karthus, with a 52.2% win rate. Therefore, Akali makes a good counter to Karthus.
While Akali does have a higher win rate than Karthus, when they face off with one another, Akali also has a greater learning curve that makes her a more difficult champ to pick up and master. You should be be fine when picking Akali into Karthusas her relative depth means that you may not be able to reach her full potential without a lot of practice beforehand.
Additionally, Akali also has only a small amount of utility and CC, a similar amount to Karthus. This often makes her just as valuable during teamfights, especially when facing champions with a ton of burst damage.
While there is not a single best champion in League of Legends, in Akali vs Karthus matchups, Akali is the better champ with a noticably higher win rate, similar champion depth, and a similar amount of utility to help out your team members during teamfights.
Akali is a good counter for Karthus. You will do well by focussing your actions on keeping up your CS and clearing objectives. If you are able to do that, you should be able to stand on your own as Akali against Karthus.
To learn all of the intricacies of Akali in order to counter Karthus during both the lane and mid / late game phases of League of Legends, you should keep reading to learn a few extra lessons on this matchup. If you pay attention to the build and suggestions shown above, you should grow your win rate significantly and be closer to League of Legends pro players.
Akali typically picks up more CS relative to Karthus. Champs who typically don't take many minion kills usualy don't require much CS to be effective, such as supports. They are capable of scaling well off of their skills, stats, and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, typically require several high cost items to be effective. In either situation, try to exceed the values displayed here to do well.
The most important items to use in your Akali versus Karthus build include Rabadon's Deathcap, Zhonya's Hourglass, and Stormsurge. When Akali combined at least these three pieces in her build, she performed significantly better versus Karthus than with most other typical builds. In fact, Akali boasted an average win rate of 52.2% battling Karthus with this build.
To have the highest chance of annihilating Karthus as Akali, you should equip the Electrocute, Sudden Impact, Eyeball Collection, Ultimate Hunter, Overgrowth, and Second Wind runes from the Domination and Resolve rune sets. Of all the rune builds players picked for Akali vs Karthus counter picks, this composite of runes resulted in the highest win rate. Moreover, these runes provided a 52.2% winrate overall.
If you would like to view Akali vs Karthus tips and counter stats for a a particular division rank, feel free to select one from the selection menu above. At first, the statistics and guides given are computed using all rounds with data with both champions.