Vladimir's ultimate, Hemoplague, is most effective when cast during teamfights on as many enemy champions as possible.
When you anticipate an engagement with your enemy lane partner, keep one stack of Bloodthirst so that you get the empowered Transfusion when you cast it.
League of Legends Vladimir players could find him to be a challenging champion to build out properly. You'll notice that his build changes when he is fighting either generic or highly focused team compositions, indicating you should not take the same Vladimir build every game of League of Legends
The best items to incorporate into your champion's build are: Hextech Rocketbelt, Rabadon's Deathcap, and Cosmic Drive. Those who included these items in their kits had a much better winrate than those who utilized other Vladimir builds. Moreover, if you are trying to beat a well-mixed enemy team composition, you should really consider grabbing yourself the Sorcery, and Precision runes. In recent matches, he won the greatest fraction of his rounds when using these runes.
We calculated our Vladimir build suggestions by analyzing 58,684 recently ranked League of Legends matches with him in them. We only propose the top winrate Vladimir builds that were used by ranked League players enough times for us to reccomend them. With so many games in our dataset, we are confident in our suggested builds.