Ice Shard is a good harassment tool against enemy champions in lane and also helps Lissandra farm minions.
A good initiation combo is Glacial Path to close in on enemy carries, followed by Frozen Tomb to isolate them in the fight, and then Ring of Frost and Ice Shard to deal damage.
LoL Lissandra players will find her to be a confusing champ to build out properly. You'll see that her build is modified when she is playing against either generic or specialized team compositions, demonstrating you shouldn't follow the same Lissandra build every game of League of Legends
The most essential items to use in your champ's build are: Liandry's Anguish, Rabadon's Deathcap, and Zhonya's Hourglass. Those who included these pieces in their gear had a significantly better win rate than players who used other item builds for Lissandra. Moreover, if you are battling a well-mixed enemy team comp, you should strongly consider getting her the Sorcery, and Domination runes. In recent matches, she won the largest fraction of her rounds when equipped with these runes.
We set our Lissandra build recommendations by analyzing 44,429 recently ranked League matches with her in them. We only recommend the best winrate Lissandra builds that have been built by ranked League players enough times for us to advise them. With so many rounds in our dataset, we are confident in our recommended builds.