Lay Waste is a powerful skillshot that takes practice to perfect. It's worth it though because it can give you a significant advantage in mid lane.
Wall of Pain can be used to slow down enemies during teamfights or when someone helps gank your lane.
Q: What is Karthus' greatest strength?
A: While many would argue that Karthus' greatest strength is his global Ultimate that can damage everyone, no matter where they are, we'd disagree. We believe his greatest strength is his ability to deal large amounts of AoE damage, even when dead. Karthus can continue to deal damage for a long time, even after his death. Adding <a href="/item/3116/" target="_blank">Rylai's Crystal Scepter</a> into your Karthus build can slow a large number of enemies and do more DoT. Because Karthus can deal damage even when dead, he's often not the priority of the fight. Killing him won't save them.
Q: What is Karthus' greatest weakness?
A: Karthus' Q is a powerful, offensive ability with low cooldown. However, it is very skill dependent and can be dodged. Furthermore, its damage increases if only one target is hit. In teamfights and in lane, there are often other nearby enemies that dilute his single target potential. Karthus' only reliable source of damage in the middle of a teamfight is his damage aura. Use your slow to keep enemies close. To reduce the danger of diving into the enemy's back line, include <a href="/item/3157/" target=_blank">Zhonya's Hourglass</a> in your build for Karthus.
Q: Is Karthus better in lane or in the jungle?
A: In the current meta, Karthus is best in the jungle. His powerful slow will help him gank while his global Ult allows him to participate in kills anywhere on the Rift. He's not just limited to a single lane or gank opportunity.
League of Legends Karthus players could find him to be a confusing character to build out properly. You will find that his build changes when he is fighting either well-rounded or specialized team compositions, showing you should not follow the same Karthus build every game of League of Legends
The most important items to incorporate into your champion's build are: Liandry's Anguish, Rabadon's Deathcap, and Void Staff. Players who included these pieces in their gear had a better win rate than players who worked towards other item builds for Karthus. Likewise, if you are trying to beat a mixed enemy team arrangement, you should really consider grabbing yourself the Inspiration, and Domination runes. In recent games, he won the largest number of his matches when equipped with these runes.
We calculated our Karthus build guidance by examining 33,687 recently ranked League of Legends games with him in them. We only recommend the best winrate Karthus builds that were built by ranked LoL players enough times for us to reccomend them. With so many games in our data, we are confident in our suggested builds.