Cassiopeia is great at harassing and zoning enemies so make sure your enemy laner cannot last hit minions.
Maximize damage from Twin Fang by using it on stationary neutral monsters or stunned targets.
LoL Cassiopeia players will find her to be a challenging character to build out properly. You'll notice that her build changes when she is up against either diversified or specialized team comps, meaning you shouldn't follow the same Cassiopeia build every single round of League of Legends
The most critical items to use in your champion's build are: Rod of Ages, Seraph's Embrace, and Rabadon's Deathcap. Those who added these pieces in their gear had a better winrate than players who went for other Cassiopeia builds. Moreover, if you are fighting a mixed enemy team comp, you should really consider grabbing Cassiopeia the Precision, and Sorcery runes. In recent matches, she won the largest number of her matches when built with these runes.
We calculated our Cassiopeia build guidance by examining 31,277 recently ranked LoL rounds with her in them. We only advise the top winrate Cassiopeia builds that were used by ranked League players enough times for us to suggest them. With so many games in our data, we are very confident in our suggested builds.